Services Provided

All products will be processed through our sister company, ZDL, Inc.

 

 Pre-Implantation Genetic Diagnosis (PGD)

Pre-Implantation Genetic Diagnosis (PGD) is a medical procedure which allows embryos to be tested for gender-related genetic conditions, prior to being placed in the womb, giving the best opportunity to select the gender of your baby, or screen for genetic defects

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 Second Opinion Consultation

Our experts can review your semen analysis results, and give you a "second opinion" on whether or not you should continue your current course of fertility treatment. When thousands of dollars are at risk, it is always best to get as many of the facts as possible.

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 Routine Semen Analysis

Anyone who is having trouble conceiving should have a semen analysis done. In about 40% of infertile couples, the cause of the infertility lies with the males, and this could easily and quickly be diagnosed via a semen analysis.

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 Strict Sperm Morphology Evaluation

Normal sperm morphology has been shown to be predictive of IVF outcome/success. The AIA evaluates normal sperm morphology using either or both WHO standards and also strict criteria methodologies. The strict criteria is based on the shape and appearance of post-coital sperm found in the internal os. Basically, the sperm should have a smooth oval head, with no defects in the neck or tail regions. The percentage of normal sperm assessed using this method has been shown to correlate with other sperm functions such as sperm motility, binding to the egg investments and subsequent fertilization (3,4). Normal values should be greater than 14% normal sperm.

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 Sperm Reconstitution for Therapeutic Insemination

Semen preparation or reconstitution techniques are used in assisted reproduction and IUI to separate sperm, which have a normal appearance and move spontaneously, from the fluid portion of the semen in which the sperm are suspended. It is known that white blood cells, bacteria and dead sperm in semen can produce oxygen radicals that can impair fertilization of the egg.

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 Thawing and Preparation of Donor Sperm for Therapeutic Insemination

The same applies as in the case of sperm preparation done with IUI except in this case the sperm that is used is frozen-thawed and is coming from a semen donation program.

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 Isolation of High Quality Sperm using SpermPrep™ and other technologies

In order for fertilization to occur, high quality, motile spermatozoa need to be separated from the seminal specimen. Since there is great diversity in semen profiles, especially among infertile men, here at AIA, each specimen undergoes a special "tailor-made" procedure to isolate the best sperm for ART and IUI. For this purpose, we have developed numerous innovative techniques depending on the quality of the specimen. Among these are the SpermPrep I and II columns, the ZSC I, ZSC-II and Multi-ZSC technologies, all developed by our very own Research and Development Program at AIA (5,6,7). For more information on these products, please visit www.zdlinc.com

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 Gender Selection for Family Balancing

The procedure we use at the Andrology Institute of America is the sedimentation method. This procedure is similarly used for both the male and female selection and takes approximately 2hrs to process. On average, it takes 3-4 cycles to achieve a pregnancy with the sex selection technique. Our success rate is approximately 80% for the male selection and 72% for the female selection. This is not a guaranteed procedure, but it will increase your chances for a specific sex of a child. Gender selection does not damage or alter the sperm in any way, therefore, it will not affect the chances for abnormality to the fetus or the establishment of pregnancy.

See Also: Home Gender Selection Packages

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 Sperm Longevity Testing

The duration of sperm motility and overall physical activity is also an important indicator of sperm function and vitality. This is tested to ensure that sperm do not "die off" after a certain period of time.

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 Hypo-Osmotic Swelling Testing

HOS-test is used to test the integrity of the sperm cell membrane using the principle of osmotic differences. When normal sperm are placed in a hypoosmotic solution, water moves across the cell membrane into the sperm cell causing it to swell. If the membrane is damaged, then this transport of water will not occur and no swelling will take place. Thus, the percentage of swollen spermatozoa is the measure of intact membranes and hence sperm viability and fecundity (8,9).

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 Anti-sperm Antibody Testing

These are antibodies produced by the immune system that mistake sperm for invading substances and begin to attack them. The presence of anti-sperm antibodies has been shown to cause immobilization and agglutination of sperm, thereby preventing sperm from reaching the oocyte (10). Anti-sperm antibodies can be detected in serum, seminal plasma, cervical mucus and other reproductive tract fluids (tubal, follicular, uterine). It is estimated that 5-10% of male infertility is caused by antisperm antibodies and 10-15% of women with unexplained infertility have circulating sperm antibodies in their system.

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 Preparation of Sperm obtained via Retrograde Ejaculation

Retrograde ejaculation refers to the movement of seminal fluid backwards (retrograde) into the bladder instead of forward (antegrade) through the urethra during ejaculation. This is caused by the inability of the bladder neck to close tightly enough during ejaculation. In men with retrograde ejaculation, the post-orgasm urine can be collected and assessed for the presence of sperm. If sperm are present, the high-quality sperm can be isolated and, if adequate, can be used for ART procedures (11,12,13), as well as IUI, with great success.

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 Isolation and Selection of Round Spermatids for ICSI

Round spermatids are immature sperm cells which can be used for injection directly into the oocyte via ICSI. Usually this is the method of choice when there are no sperm present in the testis or epididymis. We offer a Hyper-osmotic Shrinkage Test (HYOS-test), that we developed at AIA, to identify and select round spermatids with intact membranes, for microinjection via ICSI (14).

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References

  1. Zarmakoupis-Zavos, P.N., Correa, J.R., Zarmakoupis,C.N., Zavos, P.M.: Multiple ejaculate collection via the use of a seminal collection device at intercourse vs masturbation.  Middle East Fertility Society Journal, 3(3):1-5, 1998.
  2. Zavos, P.M.:  Parameters and improvements in ejaculates collected at intercourse and the use of a silastic seminal collection device vs masturbation.  Infertility,  9(1):57-64, 1986.
  3. Kruger, T.F., Menkveld, R., Stander, F.S.H., Lombard, C.J., van der Merwe, J.P., van Zyl, J.A., Smith, K: Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertility Sterility. 46: 1118-1123.
  4. Kaskar, K., Franken, D.R., Van der Horst, G., Oehninger, S.C., Kruger, T.F., Hodgen, G.D.: The relationship between morphology, quantitative motility and zona pellucida binding potential of spermatozoa in human semen. Andrologia, 26: 1-4, 1994.
  5. Zavos, P.M., Sofikitis, N., Toda, T. and Miyagawa, I.: Selection and preparation of human spermatozoa for artificial insemination using the new and improved SpermPrep™II filtration method.  Japan J. Fertility Sterility. 37(3):14-19, 1992.
  6. Zavos, P.M.:  Preparation of human frozen-thawed specimens using the SpermPrep™ filtration method: Improvements over the conventional swim-up method.  Fertility and Sterility. 57(6):1326-1330, 1992.
  7. Zarmakoupis-Zavos, P.N., Zavos, P.M.:Can the method of sperm preparation for intrauterine insemination affect subsequent pregnancy rates? Comparisons between the SpermPrepTM and the traditional double wash method. Middle East Fertility Society Journal, 3(2):164-170, 1998.
  8. Toda, T., Sofikitis, N., Miyagawa, I., Zavos, P.M., Harada, T., Mio, Y. and Terakawa, N.:  Hypoosmotic swelling test / acrosin activity assay: Identifying subpopulations of idiopathic infertile men.  Molecular Andrology. 4:147-148, 1992.
  9. Sofikitis, N., Miyagawa, I. and Zavos, P.M.: Capacitation/acrosome reaction and outcome of hypoosmotic swelling test in human sperm. Molecular Andrology. 4:363-368, 1992.
  10. Zavos, P.M., Correa, J.R., Zarmakoupis-Zavos, P.N.: Antisperm antibody treatment mode: levels of antisperm antibodies following incubation in TEST-Yolk buffer and filtration via the SpermPrep™II method. Fertility and Sterility, 69(3):517-21, 1998. 
  11. Zavos, P.M. and Wilson, E.A.:  Retrograde ejaculation:  etiology and treatment via the use of a new noninvasive method.  Fertil. Steril., 42(4):627-632, 1984.
  12. Zavos, P.M. and Wilson, E. A.:  Retrograde ejaculation:  A new technique for collection and reconstitution of retrograde ejaculate.  Infertility, 5(4):287-296, 1983.
  13. Kofinas, G.D. and Zavos, P.M.: Retrograde ejaculation: preparation of spermatozoa for insemination from retrograde ejaculates using the new SpermPrep™ filtration method. Molecular Andrology. 4:121-126, 1992.
  14. Zavos, P.M., Barnes, F.L., Correa, J.R., Zarmakoupis-Zavos, P.N., Tesarik, J.: Methods for isolation and purification of post-ejaculate human round spermatids for possible use in intracytoplasmic round spermatid injection. Middle East Fertility Society Journal. 2:147-150, 1997.
  15. Zavos PM, Correa JR, ClarkW, Zarmakoupis-Zavos PN (1998): Sperm viability in human semen specimens cryostored at 5°C using the BioTranz container system for semen transport. Middle East Fertil. Soc. J. 31: 249-253.

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